“Then the sixth angel sounded: And I heard a voice from the four horns of the golden altar which is before God, saying to the sixth angel who had the trumpet, ‘Release the four angels who are bound at the great river Euphrates.’ So the four angels, who had been prepared for the hour and day and month and year, were released to kill a third of mankind. Now the number of the army of the horsemen was two hundred million; I heard the number of them.” Revelation 9:13-16 (NKJV)
The prophecy says a war will begin from the Euphrates River area that will kill one-third of all the people on earth. It also states that an army of 200 million soldiers will participate in this war. In other words, it will be, by far, the worst war the world has ever known. It will be 40 times World War II!